Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

Jansen, I.E.; Ye, H.; Heetveld, S.; Lechler, M.C.; Michels, H.; Seinstra, R.I.; ... ; IPGDC (2017)

Article / Letter to editor

• Parkinson's disease
• Genomics
• Whole-exome sequencing
• Loss-of-function
• Rare variants
• Functional screening
• Mitochondria
• Parkin
• alpha-synuclein
• Animal model

• All authors: Jansen, I.E.; Ye, H.; Heetveld, S.; Lechler, M.C.; Michels, H.; Seinstra, R.I.; Lubbe, S.J.; Drouet, V.; Lesage, S.; Majounie, E.; Gibbs, J.R.; Nalls, M.A.; Ryten, M.; Botia, J.A.; Vandrovcova, J.; Simon-Sanchez, J.; Castillo-Lizardo, M.; Rizzu, P.; Blauwendraat, C.; Chouhan, A.K.; Li, Y.R.; Yogi, P.; Amin, N.; Duijn, C.M. van; Morris, H.R.; Brice, A.; Singleton, A.B.; David, D.C.; Nollen, E.A.; Jain, S.; Shulman, J.M.; Heutink, P.; IPGDC
• Date: 2017-01-30
• Journal: Genome Biology
• Volume: 18
• DOI: doi:10.1186/s13059-017-1147-9