Induction and analysis of antigen-specific T cell responses in melanoma patients and animal model

Bins, A.D. (2007)

Doctoral Thesis

This thesis introduces a novel T cell vaccination method that uses a tattoo machine to inject DNA in the skin of the vaccinee. In comparison to other experimental vaccination methods DNA tattooing is very strong: besides small laboratory animals also large animals mount strong T cell responses upon tattoo DNA vaccination.

• Antigen
• Cross presentation
• DNA vaccination
• In vivo imaging
• Melanoma
• Stability
• T cells
• Tattoo
• Tetramers
• Vaccination

• All authors: Bins, A.D.
• Supervisor: Schumacher, A.N.
• Co-supervisor: Haanen, J.B.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2007-03-15
• ISBN (print): 9789087280114
• Court: LEI Universiteit Leiden