Model-based exposure-response analysis to quantify age related differences in the response to scopolamine in healthy subjects

Alvarez-Jimenez, R.; Groeneveld, G.J.; Gerven, J.M.A. van; Goulooze, S.C.; Baakman, A.C.; Hay, J.L.; Stevens, J. (2016)

Article / Letter to editor

• ageing
• cholinergic dysfunction
• healthy subjects
• NONMEM
• pharmacokinetic-pharmacodynamic modelling
• scopolamine

• All authors: Alvarez-Jimenez, R.; Groeneveld, G.J.; Gerven, J.M.A. van; Goulooze, S.C.; Baakman, A.C.; Hay, J.L.; Stevens, J.
• Date: 2016-10-31
• Journal: British Journal of Clinical Pharmacology
• Volume: 82
• Issue: 4
• Pages: 1011 - 1021
• DOI: doi:10.1111/bcp.13031