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Gai, N.; Turkbey, E.B.; Nazarian, S.; Geest, R.J. van der; Liu, C.Y.; Lima, J.A.C.; Bluemke, D.A. (2011)

T-1 Mapping of the Gadolinium-Enhanced Myocardium: Adjustment for Factors Affecting Interpatient Comparison

Article / Letter to editor
Quantitative T-1 mapping of delayed gadolinium-enhanced cardiac magnetic resonance imaging has shown promise in identifying diffuse myocardial fibrosis. Despite careful control of magnetic resonance imaging parameters, comparison of T-1 times between different patients may be problematic because of patient specific factors such as gadolinium dose, differing glomerular filtration rates, and patient specific delay times. In this work, a model driven approach to account for variations between patients to allow for comparison of T-1 data is provided. Kinetic model parameter values were derived from healthy volunteer time-contrast curves. Correction values for the factors described above were used to normalize T-1 values to a matched state. Examples of pre- and postcorrected values for a pool of normal subjects and in a patient cohort of type 1 diabetic patients shows tighter clustering and improved discrimination of disease state. Magn Reson Med 65:1407-1415, 2011. (C) 2010 Wiley-Liss,...Show moreQuantitative T-1 mapping of delayed gadolinium-enhanced cardiac magnetic resonance imaging has shown promise in identifying diffuse myocardial fibrosis. Despite careful control of magnetic resonance imaging parameters, comparison of T-1 times between different patients may be problematic because of patient specific factors such as gadolinium dose, differing glomerular filtration rates, and patient specific delay times. In this work, a model driven approach to account for variations between patients to allow for comparison of T-1 data is provided. Kinetic model parameter values were derived from healthy volunteer time-contrast curves. Correction values for the factors described above were used to normalize T-1 values to a matched state. Examples of pre- and postcorrected values for a pool of normal subjects and in a patient cohort of type 1 diabetic patients shows tighter clustering and improved discrimination of disease state. Magn Reson Med 65:1407-1415, 2011. (C) 2010 Wiley-Liss, Inc.Show less
T-1 mapping myocardial fibrosis patient T-1 comparison GFR delayed enhancement glomerular-filtration-rate nonischemic cardiomyopathy contrast enhancement delayed-enhancement mri infarction size visualization injection viability
All authors
Gai, N.; Turkbey, E.B.; Nazarian, S.; Geest, R.J. van der; Liu, C.Y.; Lima, J.A.C.; Bluemke, D.A.
Date
2011-05-31
Journal
Magnetic Resonance in Medicine
Volume
65
Issue
5
Pages
1407 - 1415
DOI
doi:10.1002/mrm.22716