COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

Tomlinson, I.P.M.; Dunlop, M.; Campbell, H.; Zanke, B.; Gallinger, S.; Hudson, T.; ... ; Houlston, R.S. (2010)

Article / Letter to editor

It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT. British Journal of Cancer (2010) 102, 447-454. doi:10.1038/sj.bjc.6605338 www.bjcancer.com Published online 17 November 2009 (C) 2010 Cancer Research UK

• colorectal cancer association polymorphism genome-wide association susceptibility locus mthfr c677t metaanalysis genes scan alleles variant lung 8q24

• All authors: Tomlinson, I.P.M.; Dunlop, M.; Campbell, H.; Zanke, B.; Gallinger, S.; Hudson, T.; Koessler, T.; Pharoah, P.D.; Niittymaki, I.; Tuupanen, S.; Aaltonen, L.A.; Hemminki, K.; Lindblom, A.; Forsti, A.; Sieber, O.; Lipton, L.; Wezel, T. van; Morreau, H.; Wijnen, J.T.; Devilee, P.; Matsuda, K.; Nakamura, Y.; Castellvi-Bel, S.; Ruiz-Ponte, C.; Castells, A.; Carracedo, A.; Ho, J.W.C.; Sham, P.; Hofstra, R.M.W.; Vodicka, P.; Brenner, H.; Hampe, J.; Schafmayer, C.; Tepel, J.; Schreiber, S.; Volzke, H.; Lerch, M.M.; Schmidt, C.A.; Buch, S.; Moreno, V.; Villanueva, C.M.; Peterlongo, P.; Radice, P.; Echeverry, M.M.; Velez, A.; Carvajal-Carmona, L.; Scott, R.; Penegar, S.; Broderick, P.; Tenesa, A.; Houlston, R.S.
• Date: 2010-01-19
• Journal: British Journal of Cancer
• Volume: 102
• Issue: 2
• Pages: 447 - 454