Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/110917

In Collections

This item can be found in the following collections:

Weiden, S. van der; Steggerda, S.J.; Pas, A.B.T.; Vossen, A.C.T.M.; Walther, F.J.; Lopriore, E. (2010)

Routine TORCH screening is not warranted in neonates with subependymal cysts

Article / Letter to editor
Background: Congenital infections are associated with a wide variety of clinical symptoms, including subependymal cysts (SEC). Objective: To determine the co-occurrence of SEC and congenital infections, as diagnosed by TORCH serologic tests and/or cytomegalovirus (CMV) urine culture. Methods: We performed a retrospective study of all neonates admitted to our neonatal intensive care unit from 1998 to 2009 in whom SEC were detected on cranial ultrasound and TORCH serologic tests and/or CMV urine cultures were performed. Results: Fifty-nine neonates fulfilled the inclusion criteria. TORCH serologic tests were performed in 69% (41/59) of cases. Urine CMV culture was performed in 68% (40/59) of cases. None of the neonates tested positive for IgM Toxoplasma gondii, Rubella and Herpes simplex virus. Positive CMV IgM titers and/or a positive urine CMV culture were detected in 2% (1/59) of neonates. Conclusion: The co-occurrence of TORCH congenital infections in infants with SEC is rare....Show moreBackground: Congenital infections are associated with a wide variety of clinical symptoms, including subependymal cysts (SEC). Objective: To determine the co-occurrence of SEC and congenital infections, as diagnosed by TORCH serologic tests and/or cytomegalovirus (CMV) urine culture. Methods: We performed a retrospective study of all neonates admitted to our neonatal intensive care unit from 1998 to 2009 in whom SEC were detected on cranial ultrasound and TORCH serologic tests and/or CMV urine cultures were performed. Results: Fifty-nine neonates fulfilled the inclusion criteria. TORCH serologic tests were performed in 69% (41/59) of cases. Urine CMV culture was performed in 68% (40/59) of cases. None of the neonates tested positive for IgM Toxoplasma gondii, Rubella and Herpes simplex virus. Positive CMV IgM titers and/or a positive urine CMV culture were detected in 2% (1/59) of neonates. Conclusion: The co-occurrence of TORCH congenital infections in infants with SEC is rare. Routine TORCH screening in neonates with SEC does not seem warranted. (C) 2010 Elsevier Ireland Ltd. All rights reserved.Show less
Subependymal cysts Congenital infection TORCH serologic testing Toxoplasmosis Rubella Cytomegalovirus Herpes simplex virus Neonate Cranial ultrasound choroid-plexus cysts periventricular pseudocysts germinal matrix ultrasound diagnosis infants germinolysis metaanalysis netherlands sonography
All authors
Weiden, S. van der; Steggerda, S.J.; Pas, A.B.T.; Vossen, A.C.T.M.; Walther, F.J.; Lopriore, E.
Date
2010-04-30
Journal
Early Human Development
Volume
86
Issue
4
Pages
203 - 207