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Mooij, Y.M. de; Haak, M.C.; Bartelings, M.M.; Twisk, J.W.; Gittenberger-de Groot, A.; Vugt, J.M.G. van; Bekker, M.N. (2010)

Abnormal Ductus Venosus Flow in First-Trimester Fetuses With Increased Nuchal Translucency Relationship With the Type of Cardiac Defect?

Article / Letter to editor
Objective. The purpose of this study was to evaluate ductus venosus flow velocities and a possible relationship with the type of cardiac defect in fetuses with increased nuchal translucency (NT). Methods. Seventy-two fetuses with normal NT and 137 fetuses with increased NT (>95th percentile) were evaluated. The ductus venosus pulsatility index for veins (Ply), late diastolic velocity (velocity during atrial contraction [a-V]), and intracardiac velocities were evaluated. In cases of pregnancy termination, a postmortem examination was performed. Cardiac defects were grouped into septal defects, left and right inflow obstruction, left and right outflow obstruction, and other defects. Data were evaluated by multilevel analysis. Results. A cardiac defect was found in 45 fetuses with increased NT. Fetuses with increased NT showed a higher ductus venosus PIV and a lower a-V compared to fetuses with normal NT (P < .05). Within the group of fetuses with increased NT, a higher PIV and a lower...Show moreObjective. The purpose of this study was to evaluate ductus venosus flow velocities and a possible relationship with the type of cardiac defect in fetuses with increased nuchal translucency (NT). Methods. Seventy-two fetuses with normal NT and 137 fetuses with increased NT (>95th percentile) were evaluated. The ductus venosus pulsatility index for veins (Ply), late diastolic velocity (velocity during atrial contraction [a-V]), and intracardiac velocities were evaluated. In cases of pregnancy termination, a postmortem examination was performed. Cardiac defects were grouped into septal defects, left and right inflow obstruction, left and right outflow obstruction, and other defects. Data were evaluated by multilevel analysis. Results. A cardiac defect was found in 45 fetuses with increased NT. Fetuses with increased NT showed a higher ductus venosus PIV and a lower a-V compared to fetuses with normal NT (P < .05). Within the group of fetuses with increased NT, a higher PIV and a lower a-V were found in cases with a cardiac defect compared to cases with a normal heart (P < .001). No differences in PIV and a-V were found between the types of cardiac defects. Intracardiac velocities showed no differences between fetuses with normal and increased NT, irrespective of the presence of a cardiac defect. Conclusions. Ductus venosus flow velocities in fetuses with increased NT are not related to a certain type of cardiac defect. This indicates that the altered ductus venosus flow velocities found in fetuses with increased NT cannot be explained by cardiac failure due to a specific altered cardiac anatomy.Show less
cardiac defect Doppler sonography ductus venosus nuchal translucency sonography chromosomally normal fetuses blood-flow normal karyotype great-arteries maternal age thickness gestation doppler heart trisomy-21
All authors
Mooij, Y.M. de; Haak, M.C.; Bartelings, M.M.; Twisk, J.W.; Gittenberger-de Groot, A.; Vugt, J.M.G. van; Bekker, M.N.
Date
2010-07-31
Volume
29
Issue
7
Pages
1051 - 1058