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Persengiev, S.; Koeleman, B.P.C.; Downes, K.; Valdigem, G.; Slik, A.R. van der; Eerligh, P.; ... ; Alizadeh, B.Z. (2010)

Association analysis of myosin IXB and type 1 diabetes

Article / Letter to editor
To date, seven studies have provided evidence for an association between the gene encoding for myosin IXB (MYO9B) and celiac disease (CD), and inflammatory bowel diseases, including single nucleotide polymorphisms (SNPs) rs2305767, rs1457092, and rs2305764. We investigated whether MYO9B is associated with T1D. The three SNPs were genotyped in Dutch samples from 288 T1D patients and 1615 controls. The A allele of SNP rs2305767A>G showed some evidence of association with T1D (nominal p for genotype = 0.06; OR carrier = 1.51,95% CI = 1.04-2.19), but not in British samples from 4301 case patients and 4706 controls (p = 0.53), or when the Dutch and UK data were pooled (N patients = 4582, N controls = 6224; Mantel-Hansel p=0.83). Furthermore, the nonsynonymous rs1545620 C>A SNP that has been associated with the inflammatory bowel disease, showed no association with T1D in British case-control set (p = 0.57). We conclude that MYO9B might not be a strong determinant of T1D, although there...Show moreTo date, seven studies have provided evidence for an association between the gene encoding for myosin IXB (MYO9B) and celiac disease (CD), and inflammatory bowel diseases, including single nucleotide polymorphisms (SNPs) rs2305767, rs1457092, and rs2305764. We investigated whether MYO9B is associated with T1D. The three SNPs were genotyped in Dutch samples from 288 T1D patients and 1615 controls. The A allele of SNP rs2305767A>G showed some evidence of association with T1D (nominal p for genotype = 0.06; OR carrier = 1.51,95% CI = 1.04-2.19), but not in British samples from 4301 case patients and 4706 controls (p = 0.53), or when the Dutch and UK data were pooled (N patients = 4582, N controls = 6224; Mantel-Hansel p=0.83). Furthermore, the nonsynonymous rs1545620 C>A SNP that has been associated with the inflammatory bowel disease, showed no association with T1D in British case-control set (p = 0.57). We conclude that MYO9B might not be a strong determinant of T1D, although there was some association in our initial Dutch study. Further studies are needed to evaluate the role of MYO9B in T1D. (C) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.Show less
Diabetes MYO9B Genetics Immunity Celiac disease Intestinal permeability myo9b gene polymorphisms celiac-disease intestinal permeability crohns-disease variants cohort populations mellitus risk mice
All authors
Persengiev, S.; Koeleman, B.P.C.; Downes, K.; Valdigem, G.; Slik, A.R. van der; Eerligh, P.; Monsuur, A.; Bruining, G.J.; Wijmenga, C.; Todd, J.A.; Roep, B.O.; Alizadeh, B.Z.
Date
2010-06-30
Journal
Human Immunology
Volume
71
Issue
6
Pages
598 - 601
DOI
doi:10.1016/j.humimm.2010.03.002