Immunotherapy for persistent viral infections and associated disease

Burg, S.H. van der; Arens, R.; Melief, C.J.M. (2011)

Article / Letter to editor

Persistent viral infections reflect a failure of the host's immune system to control infection, and in many cases, they are associated with the development of malignancies. So far, vaccines designed to boost viral immunity during chronic infection have not been successful. Infections with high-risk human papilloma viruses (e.g. HPV16) are acquired by a large segment of the population and persist in 5-10% of infected individuals, which causes the development of high-grade pre-malignant lesions. Recently we succeeded in causing regression of HPV16-induced disease in similar to 50% of chronically infected patients by a novel therapeutic vaccine. Here, we summarize the parallels in immunity against HPV and other chronic viruses and discuss the general implications of our findings for the immunotherapy of chronic infections.

• chronic hepatitis-b epstein-barr-virus regulatory t-cells cervical intraepithelial neoplasia human-papillomavirus type-16 interferon-gamma cytomegalovirus-infection infiltrating lymphocytes therapeutic vaccination transplant recipients

• All authors: Burg, S.H. van der; Arens, R.; Melief, C.J.M.
• Date: 2011-03-31
• Journal: Trends in Immunology
• Volume: 32
• Issue: 3
• Pages: 97 - 103
• DOI: doi:10.1016/j.it.2010.12.006