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Meulenbeek, P.; Spinhoven, P.; Smit, F.; Balkom, A. van; Cuijpers, P. (2010)

Cognitive mediation of panic reduction during an early intervention for panic

Article / Letter to editor
Objective: This study investigated cognitive mediation of improvement in panic disorder (PD) symptomatology during and after an early intervention for panic symptoms in subthreshold and mild PD. Method: We executed a pragmatic, pre-post, two-group, multi-site, randomized trial of an early intervention for panic symptoms, based on cognitive-behavioural therapy, vs. a wait-list control group in a sample of 217 participants with subthreshold PD or mild PD. Results: First, two of the three subscales of the mediator variable Panic Appraisal Inventory (PAI-anticipation and PAI-coping) significantly mediated residual change in PD symptomatology on the PD Severity Scale-Self Report. Second, preintervention to postintervention PAI-anticipation and PAI-coping change scores significantly predicted postintervention to follow-up change in PD symptomatology after controlling for other change scores. However, the converse association was also significant. Conclusion: The results suggest that...Show moreObjective: This study investigated cognitive mediation of improvement in panic disorder (PD) symptomatology during and after an early intervention for panic symptoms in subthreshold and mild PD. Method: We executed a pragmatic, pre-post, two-group, multi-site, randomized trial of an early intervention for panic symptoms, based on cognitive-behavioural therapy, vs. a wait-list control group in a sample of 217 participants with subthreshold PD or mild PD. Results: First, two of the three subscales of the mediator variable Panic Appraisal Inventory (PAI-anticipation and PAI-coping) significantly mediated residual change in PD symptomatology on the PD Severity Scale-Self Report. Second, preintervention to postintervention PAI-anticipation and PAI-coping change scores significantly predicted postintervention to follow-up change in PD symptomatology after controlling for other change scores. However, the converse association was also significant. Conclusion: The results suggest that changes in cognitions may mediate changes in PD symptomatology and that the process of change is circular.Show less
mediation early intervention panic disorder cognitive-behavioural therapy randomized controlled trial disorder severity scale behavioral treatment depression scale personal mastery hospital anxiety controlled-trial self-efficacy therapy agoraphobia psychotherapy
All authors
Meulenbeek, P.; Spinhoven, P.; Smit, F.; Balkom, A. van; Cuijpers, P.
Date
2010-07-31
Journal
Acta Psychiatrica Scandinavica
Volume
122
Issue
1
Pages
20 - 29
DOI
doi:10.1111/j.1600-0447.2009.01530.x