Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/109461

In Collections

This item can be found in the following collections:

Schroeff, M.P. van der; Schans, S.A.M. van de; Piccirillo, J.F.; Langeveld, T.P.M.; Jong, R.J.B. de; Janssen-Heijnen, M.L.G. (2010)

CONDITIONAL RELATIVE SURVIVAL IN HEAD AND NECK SQUAMOUS CELL CARCINOMA: PERMANENT EXCESS MORTALITY RISK FOR LONG-TERM SURVIVORS

Article / Letter to editor
Background. Dynamic predictions on head and neck cancer survival could offer, besides improved patient counseling, insight into long-term effects of tumor- and patient-based characteristics on survival. Theoretically, there could be a certain time period after diagnosis after which the patient returns to a population risk on survival. Methods. In all, 7255 patients with a primary head and neck squamous cell carcinoma (HNSCC) aged 25 to 90 years, diagnosed between January 1980 and January 2004 in The Netherlands, were included. Conditional 5-year relative survival for every additional year survived was computed. Results. The overall conditional relative prognosis reached a plateau after approximately 4 years; a permanent 20% to 25% excess mortality for long-term HNSCC survivors remained. Conclusions. Conditional 5-year relative survival for patients with HNSCC remains poorer compared to age- and sex-matched counterparts in the general population, even when alive at 15 years after...Show moreBackground. Dynamic predictions on head and neck cancer survival could offer, besides improved patient counseling, insight into long-term effects of tumor- and patient-based characteristics on survival. Theoretically, there could be a certain time period after diagnosis after which the patient returns to a population risk on survival. Methods. In all, 7255 patients with a primary head and neck squamous cell carcinoma (HNSCC) aged 25 to 90 years, diagnosed between January 1980 and January 2004 in The Netherlands, were included. Conditional 5-year relative survival for every additional year survived was computed. Results. The overall conditional relative prognosis reached a plateau after approximately 4 years; a permanent 20% to 25% excess mortality for long-term HNSCC survivors remained. Conclusions. Conditional 5-year relative survival for patients with HNSCC remains poorer compared to age- and sex-matched counterparts in the general population, even when alive at 15 years after diagnosis. We assume that this is caused by an excess comorbidity in these patients, mainly due to smoking and alcohol abuse. (C) 2010 Wiley Periodicals, Inc. Head Neck 32: 1613-1618, 2010Show less
head and neck cancer prognosis conditional survival excess mortality counseling 2nd primary malignancies cancer-patients primary tumors treatment strategy cigarette-smoking prognostic-factor period analysis pooled analysis comorbidity epidemiology
All authors
Schroeff, M.P. van der; Schans, S.A.M. van de; Piccirillo, J.F.; Langeveld, T.P.M.; Jong, R.J.B. de; Janssen-Heijnen, M.L.G.
Date
2010-12-31
Journal
Head and Neck
Volume
32
Issue
12
Pages
1613 - 1618