Genetic loci influencing kidney function and chronic kidney disease

Chambers, J.C.; Zhang, W.H.; Lord, G.M.; Harst, P. van der; Lawlor, D.A.; Sehmi, J.S.; Gale, D.P.; Wass, M.N.; Ahmadi, K.R.; Bakker, S.J.L.; Beckmann, J.; Bilo, H.J.G.; Bochud, M.; Brown, M.J.; Caulfield, M.J.; Connell, J.M.C.; Cook, H.T.; Cotlarciuc, I.; Smith, G.D.; Silva, R. de; Deng, G.H.; Devuyst, O.; Dikkeschei, L.D.; Dimkovic, N.; Dockrell, M.; Dominiczak, A.; Ebrahim, S.; Eggermann, T.; Farrall, M.; Ferrucci, L.; Floege, J.; Forouhi, N.G.; Gansevoort, R.T.; Han, X.J.; Hedblad, B.; Heide, J.J.H. van der; Hepkema, B.G.; Hernandez-Fuentes, M.; Hypponen, E.; Johnson, T.; Jong, P.E. de; Kleefstra, N.; Lagou, V.; Lapsley, M.; Li, Y.; Loos, R.J.F.; Luan, J.; Luttropp, K.; Marechal, C.; Melander, O.; Munroe, P.B.; Nordfors, L.; Parsa, A.; Peltonen, L.; Penninx, B.W.; Perucha, E.; Pouta, A.; Prokopenko, I.; Roderick, P.J.; Ruokonen, A.; Samani, N.J.; Sanna, S.; Schalling, M.; Schlessinger, D.; Schlieper, G.; Seelen, M.A.J.; Shuldiner, A.R.; Sjogren, M.; Smit, J.H.; Snieder, H.; Soranzo, N.; Spector, T.D.; Stenvinkel, P.; Sternberg, M.J.E.; Swaminathan, R.; Tanaka, T.; Ubink-Veltmaat, L.J.; Uda, M.; Vollenweider, P.; Wallace, C.; Waterworth, D.; Zerres, K.; Waeber, G.; Wareham, N.J.; Maxwell, P.H.; McCarthy, M.I.; Jarvelin, M.R.; Mooser, V.; Abecasis, G.R.; Lightstone, L.; Scott, J.; Navis, G.; Elliott, P.; Kooner, J.S.

doi:doi:10.1038/ng.566

Chambers, J.C.; Zhang, W.H.; Lord, G.M.; Harst, P. van der; Lawlor, D.A.; Sehmi, J.S.; ... ; Kooner, J.S. (2010)

Genetic loci influencing kidney function and chronic kidney disease

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

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All authors: Chambers, J.C.; Zhang, W.H.; Lord, G.M.; Harst, P. van der; Lawlor, D.A.; Sehmi, J.S.; Gale, D.P.; Wass, M.N.; Ahmadi, K.R.; Bakker, S.J.L.; Beckmann, J.; Bilo, H.J.G.; Bochud, M.; Brown, M.J.; Caulfield, M.J.; Connell, J.M.C.; Cook, H.T.; Cotlarciuc, I.; Smith, G.D.; Silva, R. de; Deng, G.H.; Devuyst, O.; Dikkeschei, L.D.; Dimkovic, N.; Dockrell, M.; Dominiczak, A.; Ebrahim, S.; Eggermann, T.; Farrall, M.; Ferrucci, L.; Floege, J.; Forouhi, N.G.; Gansevoort, R.T.; Han, X.J.; Hedblad, B.; Heide, J.J.H. van der; Hepkema, B.G.; Hernandez-Fuentes, M.; Hypponen, E.; Johnson, T.; Jong, P.E. de; Kleefstra, N.; Lagou, V.; Lapsley, M.; Li, Y.; Loos, R.J.F.; Luan, J.; Luttropp, K.; Marechal, C.; Melander, O.; Munroe, P.B.; Nordfors, L.; Parsa, A.; Peltonen, L.; Penninx, B.W.; Perucha, E.; Pouta, A.; Prokopenko, I.; Roderick, P.J.; Ruokonen, A.; Samani, N.J.; Sanna, S.; Schalling, M.; Schlessinger, D.; Schlieper, G.; Seelen, M.A.J.; Shuldiner, A.R.; Sjogren, M.; Smit, J.H.; Snieder, H.; Soranzo, N.; Spector, T.D.; Stenvinkel, P.; Sternberg, M.J.E.; Swaminathan, R.; Tanaka, T.; Ubink-Veltmaat, L.J.; Uda, M.; Vollenweider, P.; Wallace, C.; Waterworth, D.; Zerres, K.; Waeber, G.; Wareham, N.J.; Maxwell, P.H.; McCarthy, M.I.; Jarvelin, M.R.; Mooser, V.; Abecasis, G.R.; Lightstone, L.; Scott, J.; Navis, G.; Elliott, P.; Kooner, J.S.

Date: 2010-05-31

Journal: Nature Genetics

Volume: 42

Issue: 5

Pages: 373 - 375

DOI: doi:10.1038/ng.566

Leiden University Scholarly Publications

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Genetic loci influencing kidney function and chronic kidney disease