P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice

Tang, S.C.; Kort, A.; Cheung, K.L.; Rosing, H.; Fukami, T.; Durmus, S.; ... ; Schinkel, A.H. (2015)

Article / Letter to editor

• cabazitaxel
• carboxylesterase
• pharmacokinetics
• P-glycoprotein
• brain accumulation

• All authors: Tang, S.C.; Kort, A.; Cheung, K.L.; Rosing, H.; Fukami, T.; Durmus, S.; Wagenaar, E.; Hendrikx, J.J.M.A.; Nakajima, M.; Vlijmen, B.J.M. van; Beijnen, J.H.; Schinkel, A.H.
• Date: 2015-10-31
• Journal: Molecular Pharmaceutics
• Volume: 12
• Issue: 10
• Pages: 3714 - 3723
• DOI: doi:10.1021/acs.molpharmaceut.5b00470