Glycoforms of Immunoglobulin G Based Biopharmaceuticals Are Differentially Cleaved by Trypsin Due to the Glycoform Influence on Higher-Order Structure

Falck, D.; Jansen, B.C.; Plomp, R.; Reusch, D.; Haberger, M.; Wuhrer, M. (2015)

Article / Letter to editor

• glycoproteomics
• glycosylation
• trypsin substrate specificity
• tryptic cleavage
• biopharmaceuticals
• immunoglobulin G
• monoclonal antibodies
• method development
• higher-order structure
• proteolytic biases

• All authors: Falck, D.; Jansen, B.C.; Plomp, R.; Reusch, D.; Haberger, M.; Wuhrer, M.
• Date: 2015-09-30
• Journal: Journal of Proteome Research
• Volume: 14
• Issue: 9
• Pages: 4019 - 4028
• DOI: doi:10.1021/acs.jproteome.5b00573