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Anttila, V.; Stefansson, H.; Kallela, M.; Todt, U.; Terwindt, G.M.; Calafato, M.S.; ... ; Int Headache Genetics Consortium (2010)

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1

Article / Letter to editor
Migraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 x 10(-9), odds ratio = 1.23, 95% CI 1.150-1.324) in a genome-wide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis P value of 1.69 x 10(-11) (odds ratio = 1.18, 95% CI 1.127-1.244). rs1835740 is located between MTDH (astrocyte elevated gene 1, also known as AEG-1) and PGCP (encoding plasma glutamate carboxypeptidase). In an expression quantitative trait study in lymphoblastoid cell lines, transcript levels of the MTDH were found to have a significant...Show moreMigraine is a common episodic neurological disorder, typically presenting with recurrent attacks of severe headache and autonomic dysfunction. Apart from rare monogenic subtypes, no genetic or molecular markers for migraine have been convincingly established. We identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 x 10(-9), odds ratio = 1.23, 95% CI 1.150-1.324) in a genome-wide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls. The association was replicated in 3,202 cases and 40,062 controls for an overall meta-analysis P value of 1.69 x 10(-11) (odds ratio = 1.18, 95% CI 1.127-1.244). rs1835740 is located between MTDH (astrocyte elevated gene 1, also known as AEG-1) and PGCP (encoding plasma glutamate carboxypeptidase). In an expression quantitative trait study in lymphoblastoid cell lines, transcript levels of the MTDH were found to have a significant correlation to rs1835740 (P = 3.96 x 10(-5), permuted threshold for genome-wide significance 7.7 x 10(-5)). To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine.Show less
familial hemiplegic migraine lymphoblastoid cell-lines gene-expression episodic ataxia spreading depression confers risk mutation type-2 involvement mechanisms
All authors
Anttila, V.; Stefansson, H.; Kallela, M.; Todt, U.; Terwindt, G.M.; Calafato, M.S.; Nyholt, D.R.; Dimas, A.S.; Freilinger, T.; Muller-Myhsok, B.; Artto, V.; Inouye, M.; Alakurtti, K.; Kaunisto, M.A.; Hamalainen, E.; Vries, B. de; Stam, A.H.; Weller, C.M.; Heinze, A.; Heinze-Kuhn, K.; Goebel, I.; Borck, G.; Gobel, H.; Steinberg, S.; Wolf, C.; Bjornsson, A.; Gudmundsson, G.; Kirchmann, M.; Hauge, A.; Werge, T.; Schoenen, J.; Eriksson, J.G.; Hagen, K.; Stovner, L.; Wichmann, E.; Meitinger, T.; Alexander, M.; Moebus, S.; Schreiber, S.; Aulchenko, Y.S.; Breteler, M.M.B.; Uitterlinden, A.G.; Hofman, A.; Duijn, C.M. van; Tikka-Kleemola, P.; Vepsalainen; Lucae, S.; Tozzi, F.; Muglia, P.; Barrett, J.; Kaprio, J.; Farkkila, M.; Peltonen, L.; Stefansson, K.; Zwart, J.A.; Ferrari, M.D.; Olesen, J.; Daly, M.; Wessman, M.; Maagdenberg, A.M.J.M. van den; Dichgans, M.; Kubisch, C.; Dermitzakis, E.T.; Frants, R.R.; Palotie, A.; Int Headache Genetics Consortium
Date
2010-10-31
Journal
Nature Genetics
Volume
42
Issue
10
Pages
869
DOI
doi:10.1038/ng.652