This thesis illuminates painting inscriptions written in the Ming dynasty (1368-164) in a social context, revealing that inscriptions as a particular genre of text richly encompass themes... Show more This thesis illuminates painting inscriptions written in the Ming dynasty (1368-164) in a social context, revealing that inscriptions as a particular genre of text richly encompass themes relevant but not confined to social history, material culture, early modern publishing, identity construction, and self-knowledge. This thesis argues that painting inscriptions written in the Ming era are not only the result of artistic concerns; on many occasions, the production, utilization, and circulation of inscriptions had social concerns, meanings, and influences. Inscriptions as such are rich of notions, attitudes and thoughts, which can be helpful to understand Ming artists and their world, as well as an important source for scholars to explore social and intellectual history of the Ming era. This study, perhaps for the first time, brings two types of sources of inscriptions—existing paintings and textual anthologies—into the vision of academia. The two sources also represent two categories of inscriptions and their dual nature. Inscriptions are material objects with trajectories of circulation and dissemination; on the other hand, they are the texts of histories of reproduction and dissemination. The two categories of inscriptions are transmittable. A Ming painting is not a closed entity, but rather a dynamic entity. Show less
Lint, C.L. van; Boog, P.J.M. van der; Wang, W.; Brinkman, W.P.; Rovekamp, T.J.M.; Neerincx, M.A.; ... ; Dijk, S. van 2015
The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype. Here we... Show moreThe 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype. Here we present results of the pilot phase of the project, designed to develop and compare different strategies for genome-wide sequencing with high-throughput platforms. We undertook three projects: low-coverage whole-genome sequencing of 179 individuals from four populations; high-coverage sequencing of two mother-father-child trios; and exon-targeted sequencing of 697 individuals from seven populations. We describe the location, allele frequency and local haplotype structure of approximately 15 million single nucleotide polymorphisms, 1 million short insertions and deletions, and 20,000 structural variants, most of which were previously undescribed. We show that, because we have catalogued the vast majority of common variation, over 95% of the currently accessible variants found in any individual are present in this data set. On average, each person is found to carry approximately 250 to 300 loss-of-function variants in annotated genes and 50 to 100 variants previously implicated in inherited disorders. We demonstrate how these results can be used to inform association and functional studies. From the two trios, we directly estimate the rate of de novo germline base substitution mutations to be approximately 10(-8) per base pair per generation. We explore the data with regard to signatures of natural selection, and identify a marked reduction of genetic variation in the neighbourhood of genes, due to selection at linked sites. These methods and public data will support the next phase of human genetic research. Show less
