Energy restriction and Roux-en-Y gastric bypass reduce postprandial alpha-dicarbonyl stress in obese women with type 2 diabetes

Author(s):
Maessen, D.E.; Hanssen, N.M.; Lips, M.A.; Scheijen, J.L.; Dijk, K.W. van; Pijl, H. (0000-0002-3076-1551); Stehouwer, C.D.; Schalkwijk, C.G.
Published
2016
Publication type
Article / Letter to editor

Abstract

Conclusions/interpretation This study shows that type 2 diabetes is characterised by increased fasting and postprandial plasma alpha-dicarbonyl stress, which can be reduced by improving glucose metabolism through a VLCD or RYGB. These data highlight the potential to reduce reactive alpha-dicarbonyls in obese individuals with type 2 diabetes. Trial registration: ClinicalTrials.gov NCT01167959

Advanced glycation endproductsalpha-DicarbonylsObesityType 2 diabetesWeight loss interventions
Date issued
2016-09-01
Language
English
Publisher
SPRINGER
Is part of
Diabetologia (2016), Vol. 59, no. 9, p. 2013-2017
hdl
1887/99406
doi
10.1007/s00125-016-4009-1