Evaluation of an oral uracil loading test to identify DPD-deficient patients using a limited sampling strategy

Author(s):
Staveren, M.C. van; Kuilenburg, A.B.P. van; Guchelaar, H.J. (0000-0002-7085-1383); Meijer, J.; Punt, C.J.A.; Jong, R.S. de; Gelderblom, H.; Maring, J.G.
Published
2016
Publication type
Article / Letter to editor

Abstract

ConclusionsThe high sensitivity of the U/DHU ratio at t=120min for detecting DPD deficiency, as defined by DPD activity in PBMCs, showed that the oral U loading dose can effectively identify patients with reduced DPD activity.

5-fluorouracildihydropyrimidine dehydrogenasepharmacogeneticspharmacokineticsuracil
Date issued
2016-03-01
Language
English
Publisher
WILEY-BLACKWELL
Is part of
British Journal of Clinical Pharmacology (2016), Vol. 81, no. 3, p. 553-561
hdl
1887/99379
doi
10.1111/bcp.12821