Mortality in patients with Cushing's disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study

Author(s):
Clayton, R.N.; Jones, P.W.; Reulen, R.C.; Stewart, P.M.; Hassan-Smith, Z.K.; Ntali, G.; Karavitaki, N.; Dekkers, O.M.; Pereira, A.M.; Bolland, M.; Holdaway, I.; Lindholm, J.
Published
2016
Publication type
Article / Letter to editor

Abstract

Interpretation Patients with Cushing's disease who have been in remission for more than 10 years are at increased risk of overall mortality compared with the general population, particularly from circulatory disease. However, median survival from cure is excellent at about 40 years of remission. Treatment complexity and an increased number of treatments, reflecting disease that is more difficult to control, appears to negatively affect survival. Pituitary surgery alone is the preferred treatment to secure an optimum outcome, and should be done in a centre of surgical excellence.

Date issued
2016-07-01
Language
English
Publisher
ELSEVIER SCIENCE INC
Is part of
Lancet Diabetes and Endocrinology (2016), Vol. 4, no. 7, p. 569-576
hdl
1887/99352
doi
10.1016/S2213-8587(16)30005-5