Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation

Author(s):
Heuvel, J.K. van den; Boon, M.R.; Hengel, I. van; Peschier-van der Put, E.; Beek, L. van; Harmelen, V. van; Dijk, K.W. van; Pereira, A.M.; Hunt, H.; Belanoff, J.K.; Rensen, P.C.N. (0000-0002-8455-4988); Meijer, O.C. (0000-0002-8394-6859)
Published
2016
Publication type
Article / Letter to editor

Abstract

C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation. These data suggest that selective GR modulation may be a viable strategy for the reduction of diet-induced obesity and inflammation.

Date issued
2016-06-01
Language
English
Publisher
WILEY-BLACKWELL
Is part of
British Journal of Pharmacology (2016), Vol. 173, no. 11, p. 1793-1804
hdl
1887/99347
doi
10.1111/bph.13477