Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17

Author(s):
Tummers, Q.R.J.G.; Hoogstins, C.E.S.; Gaarenstroom, K.N.; Kroon, C.D. de; Poelgeest, M.I.E. van; Vuyk, J.; Bosse, T.; Smit, V.T.H.B.M.; Velde, C.J.H. van de; Cohen, A.F.; Low, P.S.; Burggraaf, J.; Vahrmeijer, A.L.
Published
2016
Publication type
Article / Letter to editor

Abstract

Conclusions: FR alpha is a favorable target for fluorescence-guided surgery as EC17 produced a clear fluorescent signal in ovarian and breast cancer tissue. This resulted in resection of ovarian cancer lesions that were otherwise not detected. Notwithstanding, autofluorescence caused false-positive lesions in ovarian cancer and difficulty in discriminating breast cancer-specific fluorescence from background signal. Optimization of the 500nm fluorophore, will minimize autofluorescence and further improve intraoperative tumor detection.

image-guided surgeryfluorescencefolate-receptor alphabreast cancerovarian cancer
Date issued
2016-05-31
Language
English
Publisher
IMPACT JOURNALS LLC
Is part of
Oncotarget (2016), Vol. 7, no. 22, p. 32144-32155
hdl
1887/99338
doi
10.18632/oncotarget.8282