Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias

Author(s):
Staal, F.J.T. (0000-0003-1588-8519); Clevers, H.
Published
2012
Publication type
Article / Letter to editor

Abstract

The Wnt-responsive transcription factors Tcf1 and Lef1 are well-known for their roles in lymphocyte development. In this issue of Immunity, Yu et al. (2012) report that Tcf1-deficient mice develop aggressive T cell lymphomas that are characterized by high Lef1 expression.

Date issued
2012-11-16
Language
English
Is part of
Immunity (2012), Vol. 37, no. 5, p. 761-3
hdl
1887/99146
doi
10.1016/j.immuni.2012.10.008