Alloreactive Effector T Cells Require the Local Formation of a Proinflammatory Environment to Allow Crosstalk and High Avidity Interaction with Nonhematopoietic Tissues to Induce GVHD Reactivity

Allogeneic stem cell transplantationGraft-versus-host diseaseCytotoxic T cellMinor histocompatibility antigensSkin biopsyICAM-1