Genetic invalidation of Lp-PLA(2) as a therapeutic target: Large-scale study of five functional Lp-PLA(2)-lowering alleles

Author(s):
Gregson, J.M.; Freitag, D.F.; Surendran, P.; Stitziel, N.O.; Chowdhury, R.; Burgess, S.; Kaptoge, S.; Gao, P.; Staley, J.R.; Willeit, P.; Nielsen, S.F.; Caslake, M.; Trompet, S.; Polfus, L.M.; Kuulasmaa, K.; Kontto, J.; Perola, M.; Blankenberg, S.; Veronesi, G.; Gianfagna, F.; Mannisto, S.; Kimura, A.; Lin, H.H.; Reilly, D.F.; Gorski, M.; Mijatovic, V.; Munroe, P.B.; Ehret, G.B.; Thompson, A.; Uria-Nickelsen, M.; Malarstig, A.; Dehghan, A.; Vogt, T.F.; Sasaoka, T.; Takeuchi, F.; Kato, N.; Yamada, Y.; Kee, F.; Muller-Nurasyid, M.; Ferrieres, J.; Arveiler, D.; Amouyel, P.; Salomaa, V.; Boerwinkle, E.; Thompson, S.G.; Ford, I.; Jukema, J.W. (0000-0002-3246-8359); Sattar, N.; Packard, C.J.; Majumder, A.A.; Alam, D.S.; Deloukas, P.; Schunkert, H.; Samani, N.J.; Kathiresan, S.; Nordestgaard, B.G.; Saleheen, D.; Howson, J.M.M.; Angelantonio, E. di; Butterworth, A.S.; Danesh, J.; CKDGen Consortium; Int Consortium Blood Pressure; CHARGE Inflammation Working Grp; MICAD Exome Consortium; EPIC-CVD Consortium; CHD Exome Consortium
Published
2017
Publication type
Article / Letter to editor
Human geneticstarget validationcoronary heart diseaselipoprotein-associated phospholipase A(2)darapladib
Date issued
2017-03-31
Language
English
Is part of
European Journal of Preventive Cardiology (2017), Vol. 24, no. 5, p. 492-504
hdl
1887/95089
doi
10.1177/2047487316682186