Early detection of asthma exacerbations by using action points in self-management plans

Abstract

Our aim was to validate optimal action points in written action plans for early detection of asthma exacerbations.We analysed daily symptoms and morning peak-flows (PEF) from two previous studies. Potential action points were based on analysis of symptom scores (SDs) percentage of personal best PEF, or PEF variability in relation to a run-in period, or combinations of these measures. Sensitivity and specificity for predicting exacerbations were obtained for each action point. The numbers needed to treat to prevent one exacerbation and the time interval between reaching action point criteria and the start of the exacerbation were calculated. Based on these parameters, the optimal action points for symptoms, PEF, and PEF plus symptoms were determined, and their performance compared to published guidelines action points.The optimal action points were: for symptoms, statistical variability (SDs); for PEF, <70% of personal best. The combination of PEF plus symptoms performed best, with improved specificity and earlier detection. The main benefits associated with using these action points was to reduce false positive rates for detecting exacerbations.Early detection of asthma exacerbations can be improved using a composite action point comprising symptoms and PEF measurements over one week.