Coagulopathy and blood abnormalities in cancer and inflammation

Abstract

Cells, their fragments and secreted factors may all be transported to distant sites via the blood circulatory system and exert their action far away from the site of origin. Identification of these mediating factors and unraveling of the pathogenesis resulting in organ damage will contribute to our general understanding and may ultimately result in new treatment strategies. The studies included in this thesis focus on mechanisms of coagulopathy and other blood abnormalities in patients with cancer or inflammation.