Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose

Liu, Q.; Marel, G.A. van der; Filippov, D.V. (2019)

Article / Letter to editor

ADP-ribosylation is an important post-translational modification that plays a pivotal role in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis. Although chemical synthesis of mono- or poly-ADP-ribosylated biomolecules is extremely difficult due to the challenges in regio- and stereoselective glycosylation, suitable protective group manipulations and pyrophosphate construction, synthetic procedures towards these bio-related targets have been reported in recent years. Chemically synthesized well-defined ADP-ribose derivatives serve as useful tools in biological experiments aimed to further elucidate native ADP-ribosylation. In this review, we will discuss the synthetic studies on mono-ADP-ribosylated proteins and oligo-ADP-ribose chains. Future possible synthetic targets and upcoming new methods for the synthesis of these molecules are also included.

• All authors: Liu, Q.; Marel, G.A. van der; Filippov, D.V.
• Date: 2019-05-13
• Journal: Organic and Biomolecular Chemistry
• Volume: 17
• Issue: 22
• Pages: 5460 - 5474
• DOI: doi:10.1039/c9ob00501c
• Link: https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB00501C#!divAb...