Immunogenicity and tumorigenicity of pluripotent stem cells

Author(s):
Kooreman, N.G.
Published
2020
Publication type
Doctoral Thesis

Abstract

This dissertation gives a detailed description of the immunogenic and tumorigenic properties of pluripotent stem cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). More specifically, a clinically relevant insight is given into the immune response towards pluripotent stem cells and how this immune reaction could be limited for stem cell therapies. In addition, gene and stem cell therapies are described for the treatment of peripheral artery disease and abdominal aortic aneurysms.

In the final chapter, the immunogenic and tumorigenic properties of iPSCs are used as an immunotherapy against various types of cancer.

stem cellsregenerative medicinegene therapycell therapycancer vaccine
Defense date
2020-02-13
Language
English
Supervisor(s)
Hamming, J.F.; Quax, P.H.A.; Wu, J.C.
Committee member(s)
Mummery, C.L.; Verhaar, M.C.; Schrepfer, S.; Goumans, M.J.T.H.; Vahrmeijer, A.L.
Qualification
Ph.D.
Degree granting institution
Leiden University of Medical Center [LUMC], Leiden University, Leiden
hdl
1887/85322
ISBN(s)
9789463613736

Funding

Sponsorship
Haaglanden Medisch Centrum Chipsoft Servier Nederland Pharma Khloris Biosciences Living with Hope Foundation Pfizer Hartstichting