Basic and clinical features of cutaneous squamous cell carcinoma in organ transplant recipients

Author(s):
Genders, R.E.
Published
2019
Publication type
Doctoral Thesis

Abstract

The risk of cutaneous squamous cell carcinoma (cSCC) is highly increased in organ transplant recipients (OTR) and these tumours carry a major health burden for these patients. This thesis dealt with several aspects of cSCC in OTR. The chapters 2 and 3 review the role of HPV in cSCC and study HPV as a prognostic factor in the aetiology of cSCC. Subsequently, diagnostic factors were studied. In chapter 4 we intended to identify p16 as a possible histopathological marker for cSCC and in chapter 5 we studied the clinical implication of pain as a symptom to differentiate cSCC from other keratinocyte lesions. In chapter 6 we reviewed the literature on metastasis risk in immunocompetent versus OTR population. We studied in chapter 7 in our own population the risk for metastasis, and subsequently risk factors, of cSCC in OTR compared to immunocompetent patients.

squamous cell carcinomaorgan transplant recipientHPVp16painmetastasis
Defense date
2019-11-21
Language
English
Supervisor(s)
Willemze, R.
Advisor(s)
Bouwes, Bavink, J.N.; Quint, K.D.
Committee member(s)
Steijlen, P.M.; Rácz, E.; Vermeer, M.H.
Qualification
Ph.D.
Degree granting institution
Leiden University of Medical Center [LUMC], Leiden University, Leiden
hdl
1887/80760
ISBN(s)
9789463805377

Funding

Sponsorship
Financial support for the printing of this thesis was kindly provided by: DDL Diagnostic Laboratory B.V., LEO Pharma BV, Olmed, Merz Pharma Benelux B.V., La Roche-Posay, Galderma Benelux B.V., Pfizer bv, Louis Widmer Nederland, ChipSoft, BAP Medical BV, Mylan HealthCare B.V, Eucerin, miraDry.