Solvent Tolerance in Bacteria: Fulfilling the Promise of the Biotech Era?

Author(s):
Kusumawardhani, H. (0000-0003-2755-5017); Hosseini, R. (0000-0002-3704-3675); Winde, J.H. de (0000-0002-7999-9317)
Published
2018
Publication type
Article / Letter to editor

Abstract

The challenge of sustainably producing highly valuable chemical compounds requires specialized microbial cell factories because many of these compounds can be toxic to microbial hosts. Therefore, solvent-tolerant bacteria are promising production hosts because of their intrinsic tolerance towards these compounds. Recent studies have helped to elucidate the molecular mechanisms involved in solvent tolerance. Advances in synthetic biological tools will enable further development of streamlined solvent-tolerant production hosts and the transfer of solvent-tolerant traits to established industrial strains. In this review, we outline challenges and opportunities to implement solvent tolerance in bacteria as a desired trait for industrial biotechnology.

Date issued
2018-05-16
Language
English
Is part of
Trends in Biotechnology (Regular edition) (2018), Vol. 36, no. 10, p. 1025-1039
hdl
1887/76193
doi
10.1016/j.tibtech.2018.04.007

Funding

Sponsorship
NWO