Lessons learnt about two-year follow-up in hand osteoarthritis: the HOSTAS study.

Author(s):
Damman, W.
Published
2019
Publication type
Doctoral Thesis

Abstract

Studies in this thesis were performed in a secondary care

cohort of patients with hand osteoarthritis. Several factors were

investigated for their association with disease status and disease

progression after two years. These factors included comorbidity, illness perceptions and MRI-defined inflammatory features such as bone marrow lesions, synovitis and joint effusion. In the MRI studies we found that these MRI-features have a clinically relevant role for their association with pain (at the same moment and after two years) and progression of radiographic damage after two years. In the second part of this thesis we evaluated the clinimetric properties of two new instruments: self-reported painful joint count and semi-automatic joint space width measurements.

Hand OsteoarthritisCohort studyMRIBone marrow lesionSynovitisEpidemiologyIllness perceptionsRadiographyClinimetricsComorbidity
Defense date
2019-05-14
Language
English
Supervisor(s)
Kloppenburg, M.; Rosendaal, F.R.
Committee member(s)
Huizinga, T.W.J.; Gussekloo, J.; Spil, W.E. van; Schiphof, D.
Qualification
Ph.D.
Degree granting institution
Leiden University of Medical Center [LUMC], Leiden University, Leiden
hdl
1887/72577
ISBN(s)
9789463234986