Supramolecular host-guest chemistry for applications in theranostics

Abstract

The possibility of

employing supramolecular interactions to solve theranostics challenges were

discussed in this work. The possibility of utilizing supramolecular host–guest

chemistry between β-Cyclodextrin and Adamantane to drive cell functionalization and cell–cell interactions in an in vitro environment was explored; the resulting pre-targeting set-up was further tested in vivo for liver radioembolization procedures. Furthermore, the self-assembly properties of ferritin were investigated to make a step towards the creation of new chemical entities that can be applied in precision therapy.