The role of the tumor suppressor Lkb1 in energy homeostatis

Author(s):
Mans, L.A.
Published
2018
Publication type
Doctoral Thesis

Abstract

The work in this thesis

describes the fundamental role of Lkb1 as a conductor of metabolism-related

processes in zebrafish larvae. We show that Lkb1 is essential for the

regulation of glucose metabolism, the activation of autophagy, and hematopoiesis under conditions of metabolic stress. Furthermore, we also uncovered gene transcription profiles and hematological characteristics that are specific to lkb1 larvae, and independent of metabolic stress. Finally, we illustrate and highlight the potential of lkb1 larvae as screening platform in research related to metabolism, hematopoiesis, and tumors bearing LKB1 mutations. Overall, we have strengthened the value of lkb1 zebrafish larvae as a model to study the effects of Lkb1-inactivation on various metabolism-related processes

MetabolismLkb1Metabolic adaptationZebrafishSynthetic lethality screenCancer metabolismAutophagyHematopoiesis
Defense date
2018-12-06
Language
English
Supervisor(s)
Meijer, A.H.
Advisor(s)
Haramis, A-P.G.
Committee member(s)
Spaink, H.P.; Richardson, M.K.; Hertog, J. den; Guigas, B.; Giles, R.
Qualification
Ph.D.
Degree granting institution
Institute of Biology Leiden (IBL), Faculty of Science, Leiden University, Leiden
hdl
1887/67528
ISBN(s)
9789082361940

Funding

Sponsorship
KWF