Monogenic models of migraine : from clinical phenotypes to pathophysiological mechanisms

Author(s):
Pelzer, N.
Published
2018
Publication type
Doctoral Thesis

Abstract

This thesis explores

clinical phenotypes and the pathophysiology of rare monogenic models of

migraine with the ultimate goal to identify novel treatment targets for these disorders, as well as for the common types of migraine. The research is divided in two parts: part one describes studies on hemiplegic migraine (HM), a monogenic form of migraine, part two describes studies on Retinal Vasculopathy with Cerebral Leukoencephalopathy and Systemic manifestations (RVCL-S), a monogenic vascular syndrome hypothesised to be associated with migraine.

MigraineNeurogeneticsHemiplegic migraineRetinal vasculopathy with cerebral leukoencephalopathy and systemic manifestationsChannelopathyEndotheliopathy
Defense date
2018-11-28
Language
English
Supervisor(s)
Ferrari, M.D.; Maagdenberg, A.M.J.M. van den
Advisor(s)
Terwindt, G.M.
Committee member(s)
Verschuren, J.J.G.M.; Duijn, C.M. van; Eikenboom, H.C.J.; Reinders, M.E.J.; Haren - Maassen van den Brink, A. van
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden Uiversity Medical Center (LUMC), Leiden University, Leiden
hdl
1887/67103
ISBN(s)
9789463324083