Neuropsychiatric symptoms and immune system parameters in Huntington's disease

Author(s):
Bouwens, J.A.
Published
2018
Publication type
Doctoral Thesis

Abstract

The aim

of this thesis was to get a better understanding of the incidence and course of

neuropsychiatric symptoms in HD, particularly irritability that is a core

behavioral symptoms. Also, we aimed to investigate the realtionship between activity of the immune system and presence of neuropsychiatric symptoms. In this thesis, the psychometric properties of the Irritability Scale, and cross sectional and longitudinal analyses of irritability are described. The role of the innate immune system was investigated using both plasma acute-phase proteins and cytokines.

Huntington's diseaseNeuropsychiatric symptomsCognitive dysfunctionCytokinesNeuro-inflammation
Defense date
2018-10-18
Language
English
Supervisor(s)
Mast, R.C. van der
Advisor(s)
Duijn, E. van; Giltay, E.J.
Committee member(s)
Wee, N.J.A. van der; Roon-Mom, W.M.C. van; Tibben, A.; Tendolkar, I.; Kremer, H.P.H.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/66270
ISBN(s)
9789463611503