Deep neuromuscular blockade and neuromuscular reversal : applications and implications

Author(s):
Boon, M.
Published
2018
Publication type
Doctoral Thesis

Abstract

Muscle relaxation is routinely applied during general

anaesthesia. The introduction of sugammadex brought new opportunities in

perioperative neuromuscular management and patient care. Sugammadex is able

to quickly and completely reverse any depth of neuromuscular block, which was not possible before. The unique properties of sugammadex enable the safe application of deep neuromuscular blockade during anaesthesia, and its intense reversal may reduce the overall incidence of postoperative residual neuromuscular blockade in the recovery ward. This thesis investigated the effect of deep neuromuscular blockade on surgical conditions in laparoscopic retroperitoneal surgery. In addition, outcome data of reversal strategies and of the everyday use of deep neuromuscular blockade are presented.

Muscle relaxantNeuromuscular blockadeNeuromuscular monitoringNeuromuscular reversalPerioperative outcome
Defense date
2018-10-10
Language
English
Supervisor(s)
Dahan, A.
Advisor(s)
Martini, C.H.
Committee member(s)
Hunter, J.M.; Scheffer, G.J.; Guchelaar, H.J.; Pelger, R.C.M.; Aarts, L.P.H.J.; Boer, H.D. de; Sarton, E.Y.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden Uiversity Medical Center (LUMC), Leiden University, Leiden
hdl
1887/66119
ISBN(s)
9789463611558

Funding

Sponsorship
MSD; RGB medical devices