Novel applications of mass spectrometry-based proteomics in clinical microbiology

Abstract

The thesis describes the

development of a number of novel mass spectrometric methods for the protein

analysis of Gram-negative bacteria. These applications are developed with the

aim of finding new and improved diagnostic routes for the typing of bacteria and their antibiotic resistance. The research is application driven and the focus is on utilizing high-end mass spectrometric instrumentation in diagnostic clinical microbiology, in a complimentary nature to already established techniques.