Forward and reverse genetics strategies for improving oncolytic reoviruses

Author(s):
Dautzenberg, I.J.C.
Published
2018
Publication type
Doctoral Thesis

Abstract

Oncolytic viruses are highly promising agents for cancer

therapy. Reovirus type 3 Dearing and adenovirus type 5 are potent

representatives of this new type of treatment. They have been tested in a

multitude of clinical trials. In these studies reovirus and adenovirus display a good safety profile, but anti-tumour efficacy should be improved. The work described in this thesis mainly concentrated on improving the entry and spread of reoviruses and adenoviruses in tumours by means of genetic modification of the viruses.

Oncolytic virusesGene therapyCancer therapyReovirusAdenovirusBaculovirus
Defense date
2018-06-14
Language
English
Supervisor(s)
Hoeben, R.C.
Advisor(s)
Wollenberg, D.J.M. van
Committee member(s)
Goumans, M.J.T.H.; Dirven, C.M.F.; Pluijm, G. van der; Hoogen, B.G. van den
Qualification
Ph.D.
Degree granting institution
Medicine / Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/62736
ISBN(s)
9789462999251