Structure-kinetic relationship studies of cannabinoid CB2 receptor agonists reveal substituent-specific lipophilic effects on residence time

Author(s):
Soethoudt, M.; Hoorens, M.W.H.; Doelman, W. (0000-0002-5138-9402); Martella, A. (0000-0002-4680-7702); Stelt, M. van der (0000-0002-1029-5717); Heitman, L.H. (0000-0002-1381-8464)
Published
2018
Publication type
Article / Letter to editor

Abstract

R agonists can be designed to have optimal kinetic profiles, which could aid the lead optimization process in drug discovery for the study or treatment of inflammatory diseases.

Date issued
2018-03-21
Language
English
Is part of
Biochemical pharmacology (2018), Vol. 152, p. 129-142
hdl
1887/61486
doi
10.1016/j.bcp.2018.03.018