Regulation of cell cycle progression by small ubiquitin-like modifiers

Abstract

The capability of cells to divide is essential for all

organisms, while uncontrolled cell proliferation can have detrimental effects

resulting in diseases like cancer. Cell division is

therefore tightly controlled by regulatory mechanisms. Post-translational modifications (PTMs) are able to directly change the function of a protein and thereby provide a quick functional switch. This thesis focusses on the roles of small ubiquitin-like modifiers (SUMOs) and their crosstalk with other post-translational modifications during cell division, at the proteome-wide level as well as the single target protein level.