Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults

Author(s):
Rongen, A. van; Brill, M.J.E.; Vaughns, J.D.; Välitalo, P.A.J.; Dongen, E.P.A. van; Ramshorst, B. van; Barrett, J.S.; Anker, J.N. van den; Knibbe, C.A.J. (0000-0001-9893-4415)
Published
2017
Publication type
Article / Letter to editor

Abstract

The clearance of cytochrome P450 (CYP) 3A substrates is reported to be reduced with lower age, inflammation and obesity. As it is unknown what the overall influence is of these factors in the case of obese adolescents vs. morbidly obese adults, we studied covariates influencing the clearance of the CYP3A substrate midazolam in a combined analysis of data from obese adolescents and morbidly obese adults.

) was evaluated.

was proposed.

is explained by increased liver blood flow. The approach characterising the influence of obesity in the paediatric population we propose here may be of value for use in future studies in obese adolescents. BACKGROUND METHODS RESULTS DISCUSSION

Date issued
2017-08-07
Language
English
Is part of
Clinical pharmacokinetics (2017), Vol. 57, no. 5, p. 601-611
hdl
1887/61124
doi
10.1007/s40262-017-0579-4