The developing heartbeat: tracing and characterization of the developing cardiac conduction system

Author(s):
Kelder, T.P.
Published
2018
Publication type
Doctoral Thesis

Abstract

In the

current thesis the embryological origin of the developing atrioventricular (AV)

canal and atrioventricular node (AVN) was investigated, using different

techniques, including immunohistochemical staining, lineage tracing and genetic characterization. In addition, the role of the RHOA-ROCK signaling pathway on development of key components of the cardiac conduction system (CCS) was studied. Finally, the potential role of the epicardium in autonomic modulation of the heartbeat was investigated.

Cardiac developmentCardiac conduction systemSupraventricular tachycardiaSinus venosus developmentAtrioventricular canal developmentRHOA-ROCK signalingEpicardiumCardiac autonomic nervous system
Defense date
2018-01-18
Language
English
Supervisor(s)
Ruiter, M.C. de; Goumans, M.J.
Advisor(s)
Jongbloed, M.R.M.
Committee member(s)
Blom, N.A.; Richardson, M.K.; Schalij, M.J.; Sedmera, D.; Kerstjens-Frederikse, W.S.
Qualification
Ph.D.
Degree granting institution
Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/58994
ISBN(s)
9789462997516