Persistent URL of this record https://hdl.handle.net/1887/58472
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction. However, the time course of a drug effect is also influenced by many other physiological processes such as the metabolism and excretion of a drug and the transduction of the relevant biological signals. In this study, we investigate when target binding kinetics are determining the time course of drug effect and generate understanding into the relation between the parameter values and the rate-limiting step in the duration of a drug effect.
- All authors
- Witte, W.E.A. de
- Supervisor
- Danhof, M.; Graaf, P.H. van der
- Co-supervisor
- Lange, E.C.M. de
- Committee
- Irth, H.; Bouwstra, J.A.; Charlton, S.J.; Vermeulen, A.; IJzerman, A.P.; Stelt, M. van der; Proost, J.H.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Leiden Academic Centre for Drug Research (LACDR) , Science , Leiden University
- Date
- 2017-12-19
- ISBN (print)
- 9789463322782
Funding
- Sponsorship
- The research described in this thesis is part of the K4DD (Kinetics for Drug Discovery) consortium which is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement no 115366. The IMI JU is a project supported by the European Union’s Seventh Framework Programme (FP7/2007–2013) and the European Federation of Pharmaceutical Industries and Associations (EFPIA).