The synthesis and biological applications of photo-activated ruthenium anticancer drugs

Author(s):
Lameijer, L.N.
Published
2017
Publication type
Doctoral Thesis

Abstract

Conventional

chemotherapy often suffers from a lack of specificity, affecting both normal

and cancer cells. Light-activated drugs provide spatial and temporal control

over their activity, providing a possible solution for this problem. This dissertation describes the synthesis and biological applications of (blue/green/red) light-activated ruthenium polypyridyl drugs as potential prodrugs against cancer.

Light activated drugsRutheniumGLUTHypoxiaCancerPDTPhotochemotherapy
Defense date
2017-12-14
Language
English
Supervisor(s)
Bouwman, E.
Advisor(s)
Bonnet, S.
Committee member(s)
Overkleeft, H.S.; Marel, G.A. van der; Szymanski, W.C.; Gasser, G.
Qualification
Ph.D.
Degree granting institution
Institue of Chemistry (LIC), Science, Leiden University, Leiden
hdl
1887/58398
ISBN(s)
9789462998025