Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics

Lange, E.C.M. de.; Brink, W.J. van den; Yamamoto, Y.; Witte, W.E.A. de; Wong, Y.C. (2017)

Article / Letter to editor

• Attrition
• mastermind research approach
• physiologically-based pharmacokinetic model
• target occupancy
• systems pharmacology
• pharmacometabolomics

• All authors: Lange, E.C.M. de.; Brink, W.J. van den; Yamamoto, Y.; Witte, W.E.A. de; Wong, Y.C.
• Date: 2017-12-31
• Journal: EXPERT OPINION ON DRUG DISCOVERY
• Volume: 12
• Issue: 12
• Pages: 1207 - 1218
• DOI: doi:10.1080/17460441.2017.1380623
• Link: https://doi.org/10.1080/17460441.2017.1380623