Hereditary breast cancer and the clinical significance of variants in the BRCA1 and BRCA2 genes

Author(s):
Moghadasi, S.
Published
2017
Publication type
Doctoral Thesis

Abstract

This thesis is aimed at improving the classification of

the variants of uncertain clinical significance in the BRCA1/2 genes.

Furthermore, it describes the optimization and standardisation of guidelines

for communication of the VUS with the counselees in clinical practice.

Hereditary_breast_cancerBRCA1BRCA2Variant_of_Uncertain_SignificanceVUSBreast_CancerMale_Breast_CancerMultifactorial_Likelihood_Model
Defense date
2017-11-30
Language
English
Supervisor(s)
Asperen, C.J. van; Devilee, P.
Advisor(s)
Vreeswijk, M.P.G.
Committee member(s)
Baas, F.; Smit, V.T.H.B.M.; Eccles, D.M.; Gomez Garcia, E.; Rookus, M.
Qualification
Ph.D.
Degree granting institution
Medicine / Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/57786
ISBN(s)
9789461828453

Funding

Sponsorship
NWO Mosaic, grant Grant 017.008.022 van de Kamp fonds, LUMC, Grant 30.925