Cellular potts modeling of complex multicellular behaviors in tissue morphogenesis

Author(s):
Hirashima, T.; Rens, E.G.; Merks, R.M.H. (0000-0002-6152-687X)
Published
2017
Publication type
Article / Letter to editor

Abstract

Mathematical modeling is an essential approach for the understanding of complex multicellular behaviors in tis- sue morphogenesis. Here, we review the cellular Potts model (CPM; also known as the Glazier-Graner-Hoge- weg model), an effective computational modeling framework. We discuss its usability for modeling complex developmental phenomena by examining four fundamental examples of tissue morphogenesis: (i) cell sorting, (ii) cyst formation, (iii) tube morphogenesis in kidney development, and (iv) blood vessel formation. The review provides an introduction for biologists for starting simulation analysis using the CPM framework.

Date issued
2017
Language
English
Is part of
Development, Growth and Differentiation (2017), Vol. 55, p. 390
hdl
1887/57660
doi
10.1111/dgd.12358
URL
http://doi.wiley.com/10.1111/dgd.12358