T cell metabolism in metabolic disease-associated autoimmunity

Author(s):
Amersfoort, J. (0000-0002-3083-4642); Kuiper, J.
Editor(s):
Amersfoort J., Kuiper J.
Published
2017
Publication type
Article / Letter to editor

Abstract

This review discusses the relevant metabolic pathways and their regulators which show potential for T cell metabolism-based immunotherapy in diseases hallmarked by both metabolic disease and autoimmunity. Multiple therapeutic approaches using existing pharmaceuticals are possible from a rationale in which T cell metabolism forms the hub in dampening the T cell component of autoimmunity in metabolic diseases. Future research into the effects of a metabolically aberrant micro-environment on T cell metabolism and its potential as a therapeutic target for immunomodulation could lead to novel treatment strategies for metabolic disease-associated autoimmunity.

T cellsCellular metabolismAutophagyDiabetesDyslipidemiaTherapeutics
Date issued
2017-10-31
Language
English
Is part of
Immunobiology (2017), Vol. 222, no. 10, p. 925-936
hdl
1887/55509
doi
10.1016/j.imbio.2017.03.001