Blood and Biomarkers in Huntington's Disease

Author(s):
Mastrokolias, A.
Published
2017
Publication type
Doctoral Thesis

Abstract

The work described in this thesis presents part of a

framework that can be used to extract

detailed disease biological information from peripheral tissue. This framework is based on the central dogma of biology “DNA to RNA to protein” and on a systems biology approach that aims to produce synergetic data whose disease pathological, prognostic and predictive value is greater than the sum of the individual experiment results. HD patients are often characterized by a multifaceted clinical profile, consisting of several symptoms and variable disease progression rates. Therefore, a systems approach such as the one described above is expected to be the most effective in identifying potential treatments and predictive biomarkers that will be most informative for the different patient subpopulations.

BiomarkersGene expressionMetabolomicsPeripheral bloodNeurodegenerative disease
Defense date
2017-09-07
Language
English
Supervisor(s)
Ommen, G.J.B. van
Advisor(s)
Roon-Mom, W.M.C. van
Committee member(s)
Dunnen, J.T. den; Meijer, O.C.; Kampinga, H.H.; Hoen, P.A.C. 't; Dorsman, J.C.
Qualification
Ph.D.
Degree granting institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, Leiden
hdl
1887/54854
ISBN(s)
9789463321952