The role of C1q in (auto) immunity

Author(s):
Schaarenburg, R.A. van
Published
2017
Publication type
Doctoral Thesis

Abstract

The complement system is an important part of the innate immune system and can be divided in three different pathways; the classical, the lectin and the alternative pathway. In this thesis the role of C1q is investigated, which is the recognition molecule of the classical pathway. With the usage of epidemiological projects the clinical presentation of C1q deficient patients is investigated and the association of C1q in patients with Neuropsychiatric Systemic Lupus Erythematosus. Furthermore, using cellular based project the production and secretion of C1q by (non) immune cells is determined. Overall, this thesis is a nice overview about the importance of C1q in keeping the homeostasis and the role of C1q in disease.

ComplementSLEC1qAntibodiesImmunityAutoimmune diseaseImmunodeficiency
Defense date
2017-04-12
Language
English
Supervisor(s)
Toes, R.E.M.; Huizinga, T.W.J.
Advisor(s)
Trouw, L.A.
Committee member(s)
Kooten, C. van; Lankester, A.C.; Wouters, D.; Steup-Beekman, G.M.; Rooijakkers, S.H.M.; Parren, P.W.H.I.
Qualification
Ph.D.
Degree granting institution
Medicine, Leiden University, Leiden
hdl
1887/48287
ISBN(s)
9789462955905